CommaSil®C4 300 Å HPLC Column employs a unique bonding process and fully capping technology to achieve a high degree of coverage of the bonded phase, effectively eliminating the influence of residual silica hydroxyl groups on the analysis. The 300 Å pore size is especially suitable for separating peptide and protein samples, demonstrating strong retention capabilities for both hydrophobic and polar compounds. Additionally, the unique double end-capping technology minimize the impact of residual silica hydroxyls and ensuring excellent peak shapes for the separation of basic and strongly polar compounds. Overall, CommaSil® C4 300 Å HPLC Column is highly suitable for separating peptide and protein samples, maintaining sharp peak shapes while offering excellent selectivity for both hydrophobic and polar compounds.