Chiral Columns
This range consists of the Diacel group of Chrials columns; Ciralcel, Chiralpak and Chrialcap. DAICEL chiral HPLC columns are the most referenced chiral HPLC columns. Used for their high quality, broad selectivity, durability, and high loading capacities, they separate > 99% of all racemic compounds.
CHIRALPAK® AGP
CHIRALPAK® AGP is the second generation chiral separation column based on the use of α1-acid glycoprotein (AGP) as the CSP. Through a patented process α1-AGP has been immobilized on porous, spherical silica particles (5μm). The surface chemistry of the silica proves a stable chiral separation material with extremely broad applicability.
ENANTIOSELECTIVITY
Racemic amines, acids and nonprotolytic compounds can be resolved directly, without derivatization. The column enables resolution of a very large number of chiral compounds from different compound classes. This is due to the unique nature of the CSP, and the fact that enantioselectivity can be induced by choosing a proper mobile phase composition.
With the new DAICEL immobilized polysaccharide-derived Chiral Stationary Phase (CSP), the user gains compatibility with all solvents in addition to highly selective Chiral Stationary Phases for enantiomer resolution, which results in an extremely versatile range of CSP’s.
The predecessors to the new generation of immobilized columns, traditional CHIRALPAK® and CHIRALCEL® DAICEL coated polysaccharide Chiral Stationary Phases are made with a spherical high-quality silica support onto which the polymeric chiral selector (amylose or cellulose derivatives) is physically coated. Due to the coated nature of these chiral supports, solvents should be carefully selected.
CHIRALPAK® AD-3, AS-3 & CHIRALCEL® OD-3, OJ-3
CHIRALPAK® AD-3, AS-3 & CHIRALCEL® OD-3, OJ-3 are columns with Chiral Stationary Phase coated on a new 3µm silica support for:
- Fast analysis
- Higher resolution
- Direct use in most HPLC systems
- Direct method transfer between 5 µm and 3 µm
- As always, DAICEL high quality
Spherisorb Chiral-1 phase
Cyclobond
CYCLOBOND is the name given to Astec technology for bonding cyclodextrins to a high-purity silica gel through a stable ether linkage. Introduced in 1983, this patented stationary phase retains the ability to form inclusion complexes and allows for numerous chemical separations by selectively including into the cyclodextrin cavity, from solution, a wide variety of organic molecules. CYCLOBOND I are β-cyclodextrin bonded and CYCLOBOND II are γ-cyclodextrin bonded.
CYCLOBOND I 2000 series of HPLC columns is specially formulated to meet today's stringent requirements for analysis in the pharmaceutical industry, and for small analytes of general interest in the chemical and environmental areas. Astec has focused on the need to accurately and reproducibly separate enantiomers. The result is a high-performance range of chiral separation phases with guaranteed batch-to-batch reproducibility, greater stability, and improved selectivity and resolution. Based on the original CYCLOBOND I (β-cyclodextrin) columns, the CYCLOBOND I 2000 series are second-generation products. The native β-cyclodextrin and eight β-cyclodextrin derivatives are in the CYCLOBOND I 2000 series.
CYCLOBOND II series columns are excellent chiral selectors for multi-ring structures such as those based on anthracene, chrysene, or pyrene. These are γ-cyclodextrin bonded phases and consist of 8 glucopyranose units arranged in the same truncated cone shape. Applications include steroids, porphyrins, FMOC amino acids. Applications for CYCLOBOND II AC, an acetylated derivative, include napthylethylamine, steroids, and sterols.
Phases (ordering information)
CYCLOBOND I 2000
- CYCLOBOND I 2000
- CYCLOBOND I 2000 AC
- CYCLOBOND I 2000 SP
- CYCLOBOND I 2000 RSP
- CYCLOBOND I 2000 HP RSP
- CYCLOBOND I 2000 DMP
- CYCLOBOND I 2000 DM
- CYCLOBOND I 2000 DNP
CYCLOBOND II
- CYCLOBOND II
- CYCLOBOND II AC